Zero G, the company that made her says no. Probably because they aren't bundling her with a Mac compatible editor, but they probably haven't included a Mac installer either, which will leave you without a way to install her on your Mac even if you did purchase VOCALOID Editor for Cubase for Mac. Another option that could work, maybe, is using a Windows compatibility layer (like WINE or CrossOver) or a virtualization environment (like Parralells, VirtualBox or VMware Fusion). If you're lucky after installing you could copy the files back to a place where the VOCALOID Editor for Cubase for Mac could load then, but if there's DRM on Avanna, that wouldn't work and you'd have to run your whole DAW on that virtual machine or compatibility layer (which would worry me with regards to latency). Feeding Frenzy Mac Full Version more.

If I were you I wouldn't rely on this without trying it out first, and unfortunatly Zero G doesn't offer demos, that I know of. The final option, the one I would recommend, is using Boot Camp to install Windows alongside OSX on your computer. You can find info on how to do this. Nothing has really changed much in the past year or so. Like said, your choices for the editing software are going to be either Piapro Studio (which comes bundled with most Crypton V4 libraries) or Vocaloid4 Editor for Cubase (which is a separate purchase).